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Updated: Jan 2, 2026

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
Published on: May 10, 2021
[Indicators of lipid exchange as early markers of development calcific aortic valve disease.]
N I Gulyaev1, I B Oleksyuk1, K L Kozlov1,2
1S.M.Kirov Military Medical Academy, 6 Acad. Lebedeva str., St. Petersburg 194044, Russian Federation,
Abstract:
A comprehensive study of lipidograms of 36 patients with initial signs of calcification of aortic semilunium was performed. It was determined that the content of apolipoprotein A-1 was significantly lower in comparison with the control groups, which requires further studies of the evaluation of the effect on the process of early development of calcification of drugs capable to increasing its content. If the concentration of apolipoprotein A-1 is less than 1,1 mg/dl and/or the apoB/apoA ratio is increased by more than 1, it is advisable to recommend dispensary follow-up with regular (no less than 1 time in 5 years) echocardiographic study with a detailed study of the functional state of the aortic valve.
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