[Alzheimer's disease therapy: challenges and perspectives.]

Here we review both clinically applied and newly emerging approaches for Alzheimer's disease management. Alzheimer's disease or Alzheimer's type dementia is the most common type of primary dementia affecting late and senile age. Hallmarks of the disorder include progressive memory loss and highest nervous activity disruption; these cause dramatic consequences to the psychological activity. The disease course is characterized by continuous (lasting years and decades) decline, increasing degree of disability, and eventual death. Despite long-lasting attempts, researchers and medical professionals were not able to elaborate effective treatment so far. The problem is tightly connected to elucidating of Alzheimer's disease molecular mechanisms as well as development of novel therapeutics and early diagnostics approaches.