Prime Time for Dimeric Cytohesins: Surveying the Membrane with One Foot at a Time
Madhanagopal Anandapadamanaban1, Roger L Williams1
1MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Structure (London, England : 1993)
|December 5, 2019
Abstract:
In this issue of Structure, Das et al. (2019) probe the structure and dynamics of dimeric cytohesins (guanine nucleotide exchange factors for ADP-ribosylation factors), in solution and on membranes. Unleashing an arsenal of methods, they demonstrate that a pleckstrin-homology domain-mediated membrane recruitment promotes conformational changes that prime cytohesins for allosteric activation.
