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Dexfenfluramine and body weight regulation: experimental study with hoarding behavior
M Fantino1, H Boucher, F Faïon
1Laboratoire de Neurobiologie des Comportements Alimentaires, Université de Bourgogne, Faculté de Médecine de Dijon, France.
Clinical Neuropharmacology
|January 1, 1988
Abstract:
At very low doses dexfenfluramine, a serotonin agonist, is a potent inhibitor of hoarding behavior. The dose able to suppress 40% of this food motivated response (ED 40) is approximately 0.3 mg/kg. The action of dexfenfluramine is mediated through serotoninergic receptors because it is suppressed by a pretreatment with metergoline, a selective serotonin-receptor blocker, but is not modified by haloperidol, a dopamine antagonist.