[Sézary syndrome. Clinical, immunological and proliferative kinetics]

The development of Sézary syndrome was observed in a patient with mycosis fungoides. The Sézary cells in the peripheral blood were identified as a specific T-cell population with helper cell characteristics. Autoradiographic analysis showed that the Sézary cells obtained from skin biopsies proliferated much more rapidly than those from the peripheral blood. After transformation into a highly malignant T-cell lymphoma (immunoblastic) it came to an abrupt and fatal course of the disease.