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Resistant Hypertension in Clinical Practice in India: Jaipur Heart Watch
Rajeev Gupta1, Krishna K Sharma2, Shubham Soni3
1Chairman, Preventive Cardiology and Internal Medicine, Eternal Heart Care Centre and Research Institute, Jaipur, Rajasthan , Corresponding Author.
Insights
Resistant hypertension is common in Indian secondary care, affecting nearly 20% of patients. This condition is significantly more prevalent in older individuals and women.
Area of Science:
- Cardiology
- Public Health
- Epidemiology
Background:
- Hypertension prevalence is high in India.
- The frequency of resistant hypertension in India remains understudied.
- Understanding resistant hypertension is crucial for public health initiatives.
Purpose of the Study:
- To determine the prevalence of resistant hypertension in a secondary-care setting in India.
- To identify demographic factors associated with resistant hypertension.
Main Methods:
- A registry-based study was conducted at a single center.
- Included 3073 patients with a primary diagnosis of hypertension.
- Resistant hypertension defined as uncontrolled blood pressure (BP ≥140/90) on 3 or 4+ antihypertensive medications, including a diuretic.
Main Results:
- The prevalence of resistant hypertension was 19.4% using the standard definition.
- Resistant hypertension was more common in women (23.5%) compared to men (15.7%).
- Older patients (>60 years) and women showed a higher likelihood of resistant hypertension.
Conclusions:
- Resistant hypertension is highly prevalent in Indian secondary-care practices.
- Older age and female sex are significant risk factors for resistant hypertension.
- Further research is needed to explore management strategies for this population.
Background:
Hypertension is highly prevalent in India but frequency of resistant hypertension has not been well studied.
Methods:
We performed a registry-based study at a single center in patients with primary diagnosis of hypertension (n=3073). Details of co-morbidities, medications and blood pressure (BP) control were obtained. Patients with coronary heart disease, cerebrovascular disease and chronic kidney disease were excluded. Resistant hypertension was defined as uncontrolled hypertension (BP ≥140/90) with use of 3 drugs of which one was a diuretic, or any 4 drugs.
Results:
Mean age of patients was 59±13 years, 47% were women and 26% <50y age. Diabetes was in 31.1%, hypothyroidism in 7.9% and chronic obstructive lung disease in 4.3%. The drugs prescribed were angiotensin converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB) in 61.5%, beta blockers in 49.8%, dihydropyridine calcium channel blockers (CCB) in 46.8%, ARB in 44.4%, diuretics in 32.1% ACEi in 13.4%, other CCBs in 2.6% and mineralocorticoid receptor antagonists (MRA) in 1.1%. One antihypertensive drug was prescribed in 27.4%, two in 41.2%, three in 18.6% and four or more in 5.4%. Prevalence of resistant hypertension using standard definition was 19.4% (95% confidence interval, CI, 18.0-20.8%). It was more in women (23.5%) vs men (15.7%) (p<0.001). Using the alternate definition the prevalence was 6.3% (95% CI 5.3-7.0%) and also more in women (6.9%) vs men (5.4%). Resistant hypertension was more common in patients >60 years (odds ratio 1.36, 95% CI 1.18-1.58) and women (odds ratio 1.64, 95% CI 1.37-1.97).
Conclusion:
Prevalence of resistant hypertension is high in a secondary-care practice in India. It is significantly greater among older patients and women.
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