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Updated: Jul 31, 2026

Isolation of Human Umbilical Vein Endothelial Cells HUVEC
Published on: April 28, 2007
RETRACTED: KLF4/Ch25h axis activated by metformin suppresses EndoMT in human umbilical vein endothelial cells
Beixin Yu1, Yingying Wu1, Zhao Li1
1The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, Guangdong, China.
Abstract:
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the authors. The authors found that the experiment to show that HG decreased CD31 (Figure 1 E) and increased Vimentin (Figure 1 F) mRNA level could not be repeated. Moreover, they found that HG had no effect on Ch25h protein level and cannot repeat the experiments that HG decreased Ch25h mRNA level (Figure 1 G). In summary, they cannot conclude that HG suppressed EndoMT through KLF4/Ch25h, which made great weakening to the protection of KLF4/Ch25h axis in blood glucose dysfunction-induced endothelial dysfunction and diabetes. The authors wish to apologize for any inconvenience they may have caused.
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