Related Experiment Video
Updated: Jan 2, 2026
Author Spotlight: Rabies-Specific Antibody Isotypes Detection in Sera or Cerebral Spinal Fluid Using an IFA Test
Published on: January 19, 2024
Serologic Response of 2 Versus 3 Doses and Intradermal Versus Intramuscular Administration of a Licensed Rabies
Timothy P Endy1, Paul B Keiser2, Dongliang Wang3
1Departments of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, New York, USA.
Background:
The World Health Organization recommends intradermal (ID) administration of rabies vaccine for preexposure prophylaxis.
Methods:
In a randomized trial in adults assigned to 1 of 6 treatment groups (ID vs intramuscular [IM], 2 vs 3 doses, and controls), rabies neutralizing antibody titers were measured to 1 year postvaccination.
Results:
ID vaccination produced acceptable antibody levels in all subjects (2- and 3-dose groups). At day 365, acceptable levels were 40% for IM and 50% for ID 2-dose schedule, and 70% for IM and 60% for ID 3-dose schedule.
Conclusions:
ID rabies vaccination induces acceptable antibody titers at a fraction of the dose.
Clinical Trials Registration:
NCT02374814.
