Related Experiment Video
Updated: Jan 2, 2026
Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel
Published on: June 29, 2015
Moderate Intensity Static Magnetic Fields Prevent Thrombus Formation in Rats and Mice
Qin Li1, Zhongcai Liao2, Lili Gu1
1Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou, P.R. China.
Abstract:
We established three types of thrombosis models to explore the effects of the static magnetic field (SMF) on thrombosis in rats and mice with three different MF intensities. In the carrageenan-induced thrombosis model in rats, the SMF treatments reduced the black tail length of rats, extracorporeal thrombus, and the mass of wet and dry thrombus, and improved the coagulation index value. In FeCl3 -induced arterial thrombosis model in rats, the SMF treatment showed some anti-thrombotic effects. More specifically, the SMF treatment affected rodent blood pressure, plasma plasminogen activator inhibitor, tissue-type plasminogen activator, thrombus mass, and thrombus protein content. In the adrenaline-induced thrombosis model in mice, the SMF treatment had certain effects on the diameter and blood flow velocity of mouse auricle microcirculation in fine veins and arteries. Overall, the highest MF intensities we tested, 20-150 mT, showed a trend of anti-thrombotic effect, indicating that the moderate-intensity SMF might serve as a potential treatment for clot-related diseases in the future. Bioelectromagnetics. 2020;41:52-62 © 2019 Bioelectromagnetics Society.
Insights
Static magnetic field (SMF) exposure demonstrated anti-thrombotic effects in rodent models. Moderate-intensity SMF may offer a future therapeutic strategy for clot-related diseases.
Area of Science:
- Biophysics
- Cardiovascular Research
- Medical Physics
Background:
- Thrombosis, the formation of blood clots, is a significant cause of morbidity and mortality.
- Investigating non-invasive therapeutic modalities for thrombosis is crucial.
- Static magnetic fields (SMF) have potential biological effects that warrant exploration in thrombosis models.
Purpose of the Study:
- To investigate the anti-thrombotic effects of static magnetic fields (SMF) in established rodent thrombosis models.
- To evaluate the impact of different magnetic field (MF) intensities on thrombosis formation and related physiological parameters.
Main Methods:
- Three thrombosis models were utilized: carrageenan-induced, FeCl3-induced arterial thrombosis in rats, and adrenaline-induced thrombosis in mice.
- SMF treatments were applied at varying intensities (20-150 mT).
- Key parameters assessed included thrombus size, mass, coagulation indices, blood pressure, and microcirculation dynamics.
Main Results:
- SMF treatment reduced thrombus burden (tail length, mass) and improved coagulation in the carrageenan model.
- In the FeCl3 model, SMF influenced blood pressure, plasma PAI, t-PA, thrombus mass, and protein content.
- SMF affected microcirculation parameters (diameter, blood flow velocity) in the adrenaline-induced model.
Conclusions:
- Static magnetic fields, particularly at moderate intensities (20-150 mT), exhibit a trend towards anti-thrombotic effects.
- These findings suggest that SMF could be a potential future therapeutic approach for managing clot-related diseases.
