Selective single C-F bond arylation of trifluoromethylalkene derivatives
Luning Tang1, Ze-Yao Liu1, Wenzhi She1
1Institute of Advanced Synthesis , School of Chemistry and Molecular Engineering , Nanjing Tech University , Nanjing 211816 , P. R. China .
Abstract:
A strategically novel single C-F bond functionalization of CF3-derived molecules, which shows a prominent advantage for the expedient construction of difluoromethylene-bridged organic scaffolds, is disclosed. The reported protocol consists of SN2' amination, N-alkylation and palladium-catalyzed allylic substitution reactions, which enables straightforward arylation and alkenylation of vinyltrifluoromethane derivatives. Furthermore, this strategy is characterized by its broad substrate scope with respect to both CF3-alkene and arylboronic acid derivatives.
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