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Related Concept Videos

Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

331
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
331

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Related Experiment Video

Updated: Jan 2, 2026

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
06:04

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation

Published on: August 8, 2025

464

Does transcatheter aortic valve alignment matter?

Jacob Andrew Salmonsmith1, Andrea Ducci1, Gaetano Burriesci1,2

  • 1UCL Mechanical Engineering, University College London, London, UK.

Open Heart
|December 6, 2019
PubMed
Summary
This summary is machine-generated.

Transcatheter aortic valve (TAV) misalignment does not significantly alter hydrodynamic performance but changes flow patterns. This may increase risks of thrombosis and plaque formation in the aortic root.

Keywords:
transcatheter aortic valvevalsalva sinusesvalve alignment

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Area of Science:

  • Cardiovascular Research
  • Biomedical Engineering
  • Fluid Dynamics

Background:

  • Transcatheter aortic valve (TAV) implantation is a key treatment for aortic valve dysfunction.
  • Accurate TAV positioning is crucial for optimal valve function.
  • Native aortic root anatomy and TAV alignment influence hemodynamics.

Purpose of the Study:

  • To investigate the impact of TAV angular alignment on post-procedure hemodynamics.
  • To analyze fluid flow patterns in relation to TAV positioning within the aortic root.

Main Methods:

  • A commercial TAV was tested in a mock aortic root with and without native leaflets.
  • Two alignment configurations were studied: commissure-to-commissure and maximum misalignment.
  • Hemodynamic data and Particle Image Velocimetry (PIV) were used for analysis.

Main Results:

  • Overall hemodynamic performance showed no significant differences between aligned and misaligned TAVs.
  • Misalignment led to altered flow patterns, including reduced central jet extension and decreased upper sinus flow (40%).
  • Increased flow stagnation was observed in the sinuses of Valsalva with TAV misalignment.

Conclusions:

  • TAV misalignment does not significantly affect hydrodynamic performance but alters intra-aortic flow dynamics.
  • Altered flow patterns may increase the risk of thrombosis and plaque formation.
  • Optimizing TAV alignment is important for mitigating potential long-term complications.