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Heparins: A Shift of Paradigm

H Coenraad Hemker1, Raed Al Dieri1, Suzette Béguin1

  • 1Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands.

Frontiers in Medicine
|December 6, 2019
PubMed
Summary

Heparins primarily inhibit thrombin generation via anti-thrombin (aIIa) activity, not anti-factor Xa (aXa). Measuring endogenous thrombin potential (ETP) could personalize heparin dosing to reduce thrombosis and bleeding risks.

Keywords:
activated partial thromboplastin time (aPTT)anti-factor Xa activityanti-thrombin activityendogenous thrombin potential (ETP)heparinlow molecular weight heparin (LMWH)personalized medicinethrombin generation

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