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Related Concept Videos

Anorexia Nervosa01:28

Anorexia Nervosa

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Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
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Individuals with anorexia nervosa commonly exhibit extreme...
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Bulimia Nervosa01:30

Bulimia Nervosa

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Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Binge Eating Disorders01:23

Binge Eating Disorders

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Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Assessing Activity-based Anorexia in Mice
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Anorexia Nervosa and Bone.

Melanie Schorr1,2, Anne Klibanski1,2

  • 1Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA.

Current Opinion in Endocrine and Metabolic Research
|December 6, 2019
PubMed
Summary
This summary is machine-generated.

Anorexia nervosa (AN) causes low bone density and fracture risk due to starvation-related endocrine changes. More research is needed to improve bone health treatments for patients with AN.

Keywords:
Anorexia nervosaBone mineral densityOsteoporosis

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Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
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Area of Science:

  • Endocrinology
  • Bone Biology
  • Psychiatry

Background:

  • Anorexia nervosa (AN) is linked to low bone mineral density and elevated fracture risk.
  • Despite diagnostic updates, high rates of low bone mass persist in AN patients.
  • Endocrine disruptions during starvation are implicated in skeletal impairment in AN.

Purpose of the Study:

  • To investigate the mechanisms behind impaired bone quality in anorexia nervosa.
  • To highlight the need for effective treatment strategies to mitigate fracture risk in AN.

Main Methods:

  • Review of current literature on AN and bone health.
  • Analysis of endocrine disturbances associated with chronic starvation.
  • Examination of skeletal integrity in AN patients.

Main Results:

  • Persistent high prevalence of low bone mass in AN.
  • Endocrine dysregulation is a key factor in bone loss.
  • AN significantly impacts skeletal integrity in both sexes.

Conclusions:

  • Understanding AN's effects on bone quality is crucial due to the disorder's severity.
  • Further research is essential for developing targeted treatments to reduce fracture risk.