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Published on: February 15, 2016
New Antiparasitic Bis-Naphthoquinone Derivatives
Jana Jentzsch1, Waleed S Koko2, Ibrahim S Al Nasr2,3
1Laboratory of Molecular Parasitology, University of Bayreuth, Universitätsstrasse 30, 95440, Bayreuth, Germany.
Abstract:
A series of bis-naphthoquinone derivatives prepared by condensation of aryl aldehydes with lawsone were tested for antiparasitic activities against Toxoplasma gondii and Trypanosoma brucei parasites. Monofluorophenyl derivative 1a, 3,4-difluorophenyl analog 1c and furyl compound 1l exhibited significant activity against T. gondii cells and appear to be new promising drug candidates against this parasite. The 3,4,5-trifluorophenyl derivative 1g and the isovanillyl derivative 1j displayed selective activity against Leishmania major amastigotes.
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