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[Patient with lower extremity artery disease : news in therapeutic approach]

Mario Maufus1, Adriano Alatri1, Marco Fresa1

  • 1Service d'angiologie, Département cœur-vaisseaux, CHUV, 1011 Lausanne.

Revue Medicale Suisse
|December 6, 2019
PubMed

Insights

The prevalence of lower extremity artery disease (LEAD) is rising, increasing risks for both limb and major cardiovascular events (MACE). New treatments show promise in reducing cardiovascular risk for high-risk patients.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Epidemiology

Background:

  • Lower extremity artery disease (LEAD) prevalence is increasing, particularly with age.
  • LEAD patients face elevated risks of major adverse limb events (MALE) and major adverse cardiovascular events (MACE).
  • Current medical treatments help mitigate, but do not eliminate, MACE risk in LEAD patients.

Purpose of the Study:

  • To evaluate the efficacy of new therapeutic molecules in reducing cardiovascular risk in LEAD patients.
  • To assess the impact of novel treatments on MACE reduction in a high-risk population.

Main Methods:

  • Review of randomized controlled trials (RCTs) investigating new therapeutic molecules for LEAD.
  • Analysis of cardiovascular risk reduction data in selected LEAD patient cohorts.

Main Results:

  • New therapeutic molecules have demonstrated a reduction in cardiovascular risk.
  • These novel treatments are effective in specific, selected patient groups with LEAD.

Conclusions:

  • Novel therapeutic agents offer a promising strategy for managing cardiovascular risk in LEAD patients.
  • Further research and clinical application of these molecules are warranted for high-risk individuals.

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