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Burn-Induced Coagulopathies: a Comprehensive Review
Robert L Ball1,2, John W Keyloun1,2,3, Kathleen Brummel-Ziedins4
1The Burn Center, MedStar Washington Hospital Center, Washington, Dist of Columbia.
Shock (Augusta, Ga.)
|December 6, 2019
Summary
Burn-induced coagulopathy lacks understanding and consensus on treatment. This review covers its effects on coagulation, fibrinolysis, and inflammation, and discusses diagnostic tests and prevention strategies.
Area of Science:
- Trauma and Burn Care
- Hematology
- Inflammation and Immunology
Background:
- Burn-induced coagulopathy is poorly understood, with limited consensus on diagnosis and treatment.
- Burn injuries significantly impact coagulation, fibrinolysis, and inflammation, particularly during acute and reconstructive care phases.
Purpose of the Study:
- To review current literature on burn-induced coagulopathy.
- To elucidate the effects of burn injury on hemostasis and inflammation.
- To discuss diagnostic methods and therapeutic strategies for burn-induced coagulopathy.
Main Methods:
- Comprehensive literature review of burn-induced coagulopathy.
- Analysis of the interplay between coagulation, fibrinolysis, and inflammation post-burn.
- Evaluation of conventional and advanced diagnostic assays (e.g., thromboelastography).
Main Results:
- Burn injury disrupts normal hemostasis, leading to complex coagulopathy.
- Interactions between coagulation, fibrinolysis, and inflammation are critical in burn care.
- Conventional tests and functional assays offer insights into coagulopathy.
Conclusions:
- Further research is needed to establish consensus on diagnosing and managing burn-induced coagulopathy.
- Understanding the pathophysiology is key to developing effective prevention and treatment strategies.
- Multifaceted approaches are required to address burn-induced coagulopathy and its complications.
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