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Spinal rosette-forming glioneuronal tumor: A case report
Shuji Hamauchi1,2, Mishie Tanino3,4, Kazutoshi Hida1
1Department of Neurosurgery, Sapporo Azabu Neurosurgical Hospital, Hokkaido.
Medicine
|December 6, 2019
Summary
Rosette-forming glioneuronal tumor (RGNT) is a rare spinal cord tumor. Complete surgical removal resulted in no recurrence at two years, highlighting RGNT as a crucial differential diagnosis for intramedullary spinal cord tumors.
Area of Science:
- Neuro-oncology
- Spinal cord pathology
- Rare tumor classification
Background:
- Rosette-forming glioneuronal tumor (RGNT) is a rare central nervous system neoplasm, recognized by the WHO since 2007.
- While typically found in supratentorial and infratentorial locations, spinal RGNTs are exceptionally infrequent, with only four prior case reports.
Observation:
- A 37-year-old female presented with progressive right-sided motor deficits.
- Cervical MRI revealed an intramedullary tumor spanning C2-C5 spinal cord levels.
Findings:
- Pathological analysis confirmed a biphasic tumor with perivascular pseudorosettes and a glial component, positive for synaptophysin, GFAP, and Olig2.
- Diagnosis of RGNT was established based on these unique histopathological features.
Implications:
- Complete resection of this spinal RGNT was achieved without adjuvant therapy.
- The patient remained recurrence-free at two-year follow-up, underscoring the importance of considering RGNT in the differential diagnosis of intramedullary spinal cord tumors.
