A Prospective, Randomized Trial Comparing Respiratory Status During Anesthesia for Airway Stenting: Spontaneous...

Area of Science:

• Anesthesiology
• Respiratory Medicine
• Interventional Pulmonology

Background:

• Airway stenting is crucial for treating airway stenosis.
• The optimal ventilation strategy during airway stenting remains debated.
• Desaturation events are a significant risk during this procedure.

Purpose of the Study:

• To compare the incidence of desaturation events between controlled ventilation with muscle relaxants (MR) and spontaneous respiration (SP) during airway stenting.
• To evaluate the impact of ventilation strategy on intraoperative respiratory parameters.

Main Methods:

• A prospective randomized interventional study involving 64 patients undergoing airway stenting.
• Patients were randomized to either controlled ventilation with MR or SP.
• Anesthesia involved total intravenous anesthesia with propofol and remifentanil.

Main Results:

• The incidence of desaturation events was significantly lower in the MR group (9.7%) compared to the SP group (75.0%).
• The MR group exhibited a more favorable intraoperative respiratory status, with higher pH and lower PaCO2 and lower PaO2/FiO2 ratios.
• Odds ratio for desaturation events was 0.04 (95% CI, 0.01-0.16; P < .001) favoring the MR group.

Conclusions:

• Controlled ventilation with muscle relaxants is a safer method for airway stenting.
• This technique effectively reduces desaturation events and improves respiratory status during the procedure.