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Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
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Candida glabrata spondylodiscitis: A case report.

Christina El Khoury1, Philippe Younes2, Rabih Hallit3

  • 1Department of Pharmacy, Bellevue Medical Center, Mansourieh, Lebanon. christina.j.elkhoury@gmail.com.

Journal of Infection in Developing Countries
|December 6, 2019
PubMed
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This case study highlights a rare fungal spondylodiscitis caused by Candida glabrata in an immunocompetent patient. Successful treatment involved surgery and antifungal therapy, demonstrating effective management for this challenging infection.

Area of Science:

  • Infectious Diseases
  • Spine Surgery
  • Mycology

Background:

  • Spondylodiscitis is an infection of the intervertebral disc and adjacent vertebral end plates.
  • Fungal infections are increasingly common, particularly in immunocompromised individuals.
  • Candida glabrata is an opportunistic fungal pathogen.

Purpose of the Study:

  • To report a rare case of fungal spondylodiscitis caused by Candida glabrata in an immunocompetent patient.
  • To describe the diagnostic and therapeutic approach for this condition.
  • To emphasize the importance of timely and appropriate management.

Main Methods:

  • Diagnosis was established via open surgical biopsy.
  • The patient underwent surgical fusion at the C4-C5 level.

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  • Treatment included intravenous micafungin followed by oral voriconazole.

    • Main Results:

    • The patient achieved a disease-free status at 6 months post-treatment.
    • Surgical fusion and a 6-month antifungal regimen were key to recovery.
    • No disease recurrence was observed within the follow-up period.

    Conclusions:

    • Fungal spondylodiscitis, especially from Candida glabrata, is rare but can occur in immunocompetent individuals.
    • Prompt diagnosis and a combination of surgical debridement, fusion, and antifungal therapy are crucial.
    • Aggressive treatment is necessary to prevent severe complications like vertebral destruction.