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Human p21-activated kinase 5 (PAK5) expression and potential mechanisms in relevant cancers: Basic and clinical

Yu-Kun Li1, Juan Zou1, Dong-Mei Ye1

  • 1Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, University of South China, Hengyang, Hunan 421001, PR China.

Life Sciences
|December 6, 2019
PubMed

Insights

p21-activated kinase 5 (PAK5) is highly expressed in various human organs and plays a significant role in cancer progression. This review details PAK5

Area of Science:

  • Molecular Biology
  • Oncology
  • Cell Biology

Background:

  • p21-activated kinase 5 (PAK5) is highly expressed in human organs like the lung, liver, and kidney, as well as in endothelial and inflammatory cells.
  • Initially detected in the cerebrum, PAK5 influences neurocyte filopodia formation and nerve axon development by interacting with Cdc42-GTP, modulating Rho activity.
  • PAK5 is implicated in diverse and complex functions within cancer development.

Purpose of the Study:

  • To review the latest knowledge on the structure, expression, and signaling pathways of PAK5.
  • To emphasize the multifaceted role of PAK5 in various types of cancer.

Main Methods:

  • Literature review of current research on PAK5.
  • Analysis of PAK5's involvement in cellular processes relevant to cancer.

Main Results:

  • PAK5 is dysregulated in numerous cancers, including ovarian, cervical, melanoma, osteosarcoma, renal, breast, and gastric cancers.
  • PAK5 influences key cancer hallmarks such as cell proliferation, apoptosis, migration, and invasion.
  • PAK5's signaling pathways and structural characteristics are crucial for its oncogenic functions.

Conclusions:

  • PAK5 is a significant mediator of cellular progression with a notable oncogenic role.
  • Understanding PAK5's structure, expression, and signaling is vital for cancer research and therapeutic strategies.
  • Further investigation into PAK5's complex functions in cancer is warranted.
Keywords:
ApoptosisCancerEMTPAK5Proliferation

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