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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Heterocyclic steroids: Efficient routes for annulation of pentacyclic steroidal pyrimidines
M Monier1, Ahmed El-Mekabaty2, Doaa Abdel-Latif1
1Chemistry Department, Faculty of Science, Taibah University, Yanbu Al-Bahr, Saudi Arabia; Chemistry Department, Faculty of Science, Mansoura University, El-Gomhoria Street, Mansoura 35516, Egypt.
Abstract:
Steroids are components of cell membranes, signaling molecules and are a type of secondary metabolites as a result of their high impact of biological significance. The present review described the literature reports of pentacyclic steroidal pyrimidines as a type of heterocyclic steroids. The main sections included the synthesis of the investigated steroids fused at rings-A or B or D of steroid skeleton, synthesis of binary or linked-type pyrimidines, pyrimidine oxides, macromolecules and mono- or di- or tri-peptides linked-steroidal pyrimidines. Besides, the present research highlighted the biological significance of steroidal pyrimidines, in which the compounds revealed potent anticancer, antioxidant, antibacterial, and anti-Alzheimer agents. In addition, some hetero-steroids were screened for binding DNA assay and gene expression analysis. It was settled that the incorporation of pyrimidine scaffold into steroid basic skeleton is crucial for better biological results.
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