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Serum ribonucleotide binding activity in osteoarthritis.
Y Tangnijkul1, L E Adams, J H Herman
1Department of Internal Medicine, University of Cincinnati Medical Center, Ohio 45267.
Clinical and Experimental Rheumatology
|July 1, 1988
Summary
Researchers found polyadenylic acid (Poly [A]) binding factors in the sera of patients with connective tissue diseases and osteoarthritis. The clinical significance of this Poly [A] binding activity remains unknown.
Area of Science:
- Immunology
- Rheumatology
- Biochemistry
Background:
- Previous studies noted ribonucleotide binding in connective tissue disease patients' sera.
- Unexpected positive responses were observed in osteoarthritic subjects.
Purpose of the Study:
- To confirm the presence of polyadenylic acid (Poly [A]) binding factors in patient sera.
- To investigate the association between Poly [A] binding and connective tissue diseases.
Main Methods:
- Utilized a radiolabelled assay for detection.
- Analyzed sera from 50 well-characterized patients with primary or secondary connective tissue diseases.
- Included matched control subjects.
Main Results:
- Confirmed the presence of Poly [A] binding factors in the sera of patients.
- No significant correlation found between serum Poly [A] binding levels and clinical or radiographic disease parameters.
Conclusions:
- Polyadenylic acid (Poly [A]) binding factors are present in sera of patients with connective tissue diseases.
- The clinical significance of serum Poly [A] binding activity is currently unknown.