Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Transcytosis of IgG

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Dual Toroidal Dipole Resonance Metamaterials under a Terahertz Domain.

Materials (Basel, Switzerland)·2018

Same author

Reduced Imaging Radiation Exposure and Costs Associated with Anti-Tumor Necrosis Factor Therapy in Crohn's Disease.

Digestive diseases and sciences·2018

Same author

The Augment of the Stability in Locking Compression Plate with Intramedullary Fibular Allograft for Proximal Humerus Fractures in Elderly People.

BioMed research international·2018

Same author

Gray Matter Structural Alterations in Social Anxiety Disorder: A Voxel-Based Meta-Analysis.

Frontiers in psychiatry·2018

Same author

Identification of two residues within the NS1 of H7N9 influenza A virus that critically affect the protein stability and function.

Veterinary research·2018

Same author

Bisphenol A induced abnormal DNA methylation of ovarian steroidogenic genes in rare minnow Gobiocypris rarus.

General and comparative endocrinology·2018

Search research articles

Related Experiment Video

Updated: Jan 2, 2026

Murine Nasal Lavage Fluid Collection without Blood Contamination

Murine Nasal Lavage Fluid Collection without Blood Contamination

Published on: July 11, 2025

Basic Research and Clinical Reports Associated with Low Serum IgG4 Concentrations.

Xinyu Tian¹, Zhenling Deng¹, Song Wang¹

¹Department of Nephrology, Peking University Third Hospital, Beijing, China.

International Archives of Allergy and Immunology

|December 6, 2019

Summary

Decreased immunoglobulin G4 (IgG4) levels, often overlooked, are linked to various inflammatory conditions. Research highlights their association with infections and systemic diseases, urging further investigation.

Keywords:

Deficiency IgG4 Immunology Inflammation Low level

More Related Videos

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

Human Serum Anti-aquaporin-4 Immunoglobulin G Detection by Cell-based Assay

Human Serum Anti-aquaporin-4 Immunoglobulin G Detection by Cell-based Assay

Published on: April 5, 2019

Related Experiment Videos

Last Updated: Jan 2, 2026

Murine Nasal Lavage Fluid Collection without Blood Contamination

Murine Nasal Lavage Fluid Collection without Blood Contamination

Published on: July 11, 2025

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

Human Serum Anti-aquaporin-4 Immunoglobulin G Detection by Cell-based Assay

Human Serum Anti-aquaporin-4 Immunoglobulin G Detection by Cell-based Assay

Published on: April 5, 2019

Area of Science:

Immunology
Clinical Medicine

Background:

Elevated serum immunoglobulin G4 (IgG4) is well-studied, but decreased IgG4 levels are frequently neglected despite their association with inflammatory diseases.
IgG4 is a unique antibody subclass with specific structural and functional characteristics.

Purpose of the Study:

To review and emphasize the clinical significance of decreased serum IgG4 concentrations.
To explore the potential causes and systemic implications of low IgG4 levels.

Main Methods:

Literature review of case reports and research studies focusing on low IgG4 levels.
Analysis of structural and functional characteristics of IgG4.

Main Results:

Low serum IgG4 levels are associated with diverse conditions, including respiratory infections, stroke, and glomerulonephritis.
Both genetic factors and immune dysregulation can lead to decreased IgG4 concentrations.
Low IgG4-related diseases can affect multiple organ systems.

Conclusions:

Decreased IgG4 levels represent a clinically relevant condition that warrants greater attention.
Further research, including animal experiments, is needed to fully understand the mechanisms and implications of low IgG4.
Recognizing low IgG4 is crucial for diagnosing and managing various infectious and noninfectious inflammatory conditions.