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Related Concept Videos

Other Disorders of Digestive System01:30

Other Disorders of Digestive System

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The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
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Gastritis-II: Pathophysiology01:17

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Celiac Disease.

Amy S Oxentenko1, Alberto Rubio-Tapia1

  • 1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN.

Mayo Clinic Proceedings
|December 7, 2019
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Summary
This summary is machine-generated.

Celiac disease (CD), affecting 1% of the population, requires a high index of suspicion for diagnosis. Early and accurate diagnosis of this multisystem disorder is crucial for effective management with a gluten-free diet.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Genetics

Background:

  • Celiac disease (CD) affects approximately 1% of the population, with most cases undiagnosed.
  • CD is a multisystem disorder with varied clinical presentations, necessitating a high index of suspicion.
  • Accurate diagnosis is critical due to the lifelong gluten-free diet management.

Purpose of the Study:

  • To provide clinicians with current information on diagnosing and managing celiac disease.
  • To cover new developments and controversial issues in celiac disease management.
  • To emphasize the importance of correct diagnosis for lifelong gluten-free diet adherence.

Main Methods:

  • Review of current literature on celiac disease diagnosis and management.
  • Analysis of diagnostic criteria including clinical features, serology, and duodenal biopsies.
  • Discussion of differential diagnoses and management strategies.

Main Results:

  • Diagnosis relies on genetic predisposition, clinical features, specific serologic findings, and duodenal enteropathy.
  • Improvement on a gluten-free diet supports the diagnosis.
  • Numerous differential diagnoses must be considered.

Conclusions:

  • Accurate diagnosis of celiac disease is paramount for effective lifelong management.
  • Clinicians need updated information on diagnostic approaches and controversial aspects of CD.
  • A multidisciplinary approach considering genetics, clinical presentation, and histology is essential.