Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.7K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.7K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.8K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.8K
Hematopoiesis01:21

Hematopoiesis

8.4K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
8.4K
Aging01:26

Aging

543
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
543
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

8.0K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
8.0K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deep learning predicts haematopoietic stem cell ageing from 3D chromatin images.

bioRxiv : the preprint server for biology·2025
Same author

Targeting RhoA nuclear mechanoactivity rejuvenates aged hematopoietic stem cells.

Nature aging·2025
Same author

A Notch trans-activation to cis-inhibition switch underlies hematopoietic stem cell aging.

Blood·2025
Same author

Haematopoietic ageing in health and lifespan.

Nature cell biology·2025
Same author

Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic hematopoietic stem cell fate.

Nature communications·2024
Same author

Transplanting rejuvenated blood stem cells extends lifespan of aged immunocompromised mice.

NPJ Regenerative medicine·2022

Related Experiment Video

Updated: Jan 2, 2026

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells
06:41

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells

Published on: May 19, 2023

2.5K

Understanding intrinsic hematopoietic stem cell aging.

Eva Mejia-Ramirez1,2, Maria Carolina Florian3,4

  • 1Center for Regenerative Medicine in Barcelona (CMRB), Bellvitge Institute for Biomedical Research (IDIBELL), Barcelona, Spain.

Haematologica
|December 7, 2019
PubMed
Summary

Aging hematopoietic stem cells (HSCs) show intrinsic changes affecting blood production. Understanding these molecular and epigenetic alterations is key to addressing age-related blood disorders.

More Related Videos

Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing
05:27

Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing

Published on: January 26, 2024

1.5K
Assessment of Cellular Bioenergetics in Mouse Hematopoietic Stem and Primitive Progenitor Cells using the Extracellular Flux Analyzer
10:17

Assessment of Cellular Bioenergetics in Mouse Hematopoietic Stem and Primitive Progenitor Cells using the Extracellular Flux Analyzer

Published on: September 24, 2021

3.1K

Related Experiment Videos

Last Updated: Jan 2, 2026

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells
06:41

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells

Published on: May 19, 2023

2.5K
Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing
05:27

Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing

Published on: January 26, 2024

1.5K
Assessment of Cellular Bioenergetics in Mouse Hematopoietic Stem and Primitive Progenitor Cells using the Extracellular Flux Analyzer
10:17

Assessment of Cellular Bioenergetics in Mouse Hematopoietic Stem and Primitive Progenitor Cells using the Extracellular Flux Analyzer

Published on: September 24, 2021

3.1K

Area of Science:

  • Hematology
  • Stem Cell Biology
  • Gerontology

Background:

  • Hematopoietic stem cells (HSCs) are crucial for lifelong blood production and maintaining hematopoietic homeostasis.
  • Intrinsic aging significantly impairs HSC self-renewal and differentiation potential, independent of the microenvironment.
  • Understanding HSC aging is vital due to the increasing elderly population and aging's role as a risk factor for diseases.

Purpose of the Study:

  • To review recent findings on intrinsic alterations in aged HSCs.
  • To highlight the evolving understanding of HSC aging beyond DNA damage.
  • To discuss the implications of HSC aging for hematologic disorders.

Main Methods:

  • Review of recent scientific literature on intrinsic HSC aging.
  • Characterization of phenotypic and molecular changes in aged HSCs.
  • Analysis of biological processes affected by aging in HSCs, including epigenetics, autophagy, proteostasis, and metabolism.

Main Results:

  • Intrinsic aging affects HSCs through phenotypic and molecular alterations.
  • Epigenetic modifications, chromatin architecture, autophagy, proteostasis, and metabolic shifts are critical factors in HSC aging.
  • These intrinsic changes contribute to the decline in HSC function over time.

Conclusions:

  • Intrinsic aging mechanisms in HSCs are complex and involve multiple interconnected biological processes.
  • Research into these mechanisms offers potential molecular targets to delay hematopoietic system aging.
  • This knowledge is crucial for improving treatments for age-related hematologic disorders like MDS and AML.