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Targeting treatable traits in severe asthma: a randomised controlled trial
Vanessa M McDonald1,2,3,4,5, Vanessa L Clark6,2,3,5, Laura Cordova-Rivera6,2,3
1National Health and Medical Research Council, Centre of Excellence in Severe Asthma, Newcastle, Australia Vanessa.McDonald@newcastle.edu.au.
The European Respiratory Journal
|December 7, 2019
Summary
Identifying and targeting treatable traits in severe asthma management significantly improves quality of life and asthma control. This personalized medicine approach offers an effective strategy for complex severe asthma cases.
Area of Science:
- Pulmonology
- Personalized Medicine
- Clinical Trials
Background:
- Treatable traits represent a novel management paradigm for airway diseases.
- Severe asthma presents complex challenges requiring tailored therapeutic strategies.
Purpose of the Study:
- To characterize treatable traits in a severe asthma population.
- To evaluate the efficacy of targeting treatments to these traits in severe asthma.
Main Methods:
- A cross-sectional study assessed treatable traits in 140 severe asthma participants.
- A 16-week randomized controlled trial (n=55) compared targeted treatment to usual care.
- Health-related quality of life was the primary endpoint.
Main Results:
- Severe asthma patients exhibited a high burden of treatable traits (mean 10.44 per person).
- Targeted individualized treatment significantly improved health-related quality of life (p<0.001) and asthma control (p=0.01).
Conclusions:
- Multidimensional assessment effectively identifies treatable traits in severe asthma.
- Targeting treatable traits via personalized medicine improves outcomes and reduces healthcare utilization.
- Treatable traits offer a promising approach for managing severe asthma complexity.
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