Related Experiment Video
Updated: Jan 2, 2026

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve
Published on: June 14, 2017
Undulating changes in human plasma proteome profiles across the lifespan
Benoit Lehallier1,2,3, David Gate4,5,6,7, Nicholas Schaum8
1Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA. lehallib@stanford.edu.
Abstract:
Aging is a predominant risk factor for several chronic diseases that limit healthspan1. Mechanisms of aging are thus increasingly recognized as potential therapeutic targets. Blood from young mice reverses aspects of aging and disease across multiple tissues2-10, which supports a hypothesis that age-related molecular changes in blood could provide new insights into age-related disease biology. We measured 2,925 plasma proteins from 4,263 young adults to nonagenarians (18-95 years old) and developed a new bioinformatics approach that uncovered marked non-linear alterations in the human plasma proteome with age. Waves of changes in the proteome in the fourth, seventh and eighth decades of life reflected distinct biological pathways and revealed differential associations with the genome and proteome of age-related diseases and phenotypic traits. This new approach to the study of aging led to the identification of unexpected signatures and pathways that might offer potential targets for age-related diseases.
Related Concept Videos
Proteomics
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Protein Buffers in Blood Plasma and Cells
Certain amino acids can exist in a zwitterion state at a...
Membrane Fluidity
Composition of Blood Plasma

