Ameliorative Effect Of Zinc Oxide Nanoparticles Against Dermal Toxicity Induced By Lead Oxide In Rats

Area of Science:

• Dermatology
• Nanotechnology
• Toxicology

Background:

• Zinc oxide (ZnO) shows potential in treating skin diseases.
• The role of ZnO nanoparticles in inflammatory skin conditions remains under-researched.
• This study investigates ZnO nanoparticles for allergic dermatitis.

Purpose of the Study:

• To evaluate the efficacy of nano zinc oxide (ZnO) cream in alleviating lead oxide (PbO)-induced allergic dermatitis in rats.
• To assess the safety and therapeutic effects of different ZnO nanoparticle (ZnONPs) concentrations.
• To confirm the pivotal role of nano zinc oxide cream in managing dermatitis.

Main Methods:

• Preparation and characterization of 1% and 6% ZnONPs creams.
• Induction of allergic dermatitis in rats using lead oxide (PbO).
• Assessment of dermal lesions, histopathology, mRNA analysis, oxidative stress markers (MDA, GSH, CAT), and immunohistochemistry (CD4, CD8, ICAM-1).

Main Results:

• PbO induced significant oxidative stress and severe allergic dermatitis, marked by increased MDA, decreased GSH and CAT, and elevated CD4+, CD8+ lymphocytes, and ICAM-1.
• Topical application of both 1% and 6% ZnONPs creams showed noticeable improvements in toxicopathological parameters.
• The 1% ZnONPs cream exhibited the most significant therapeutic effects, indicating superior efficacy.

Conclusions:

• 1% nano zinc oxide (ZnO) nanoparticles cream is safe for topical application on inflamed skin.
• ZnO nanoparticles possess anti-inflammatory and antioxidant properties.
• 1% ZnO-NPs cream is recommended for preventing and treating dermal toxicity induced by PbO.