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Ta-Coated Titanium Surface With Superior Bacteriostasis And Osseointegration
Xiao-Meng Zhang1, Yuan Li1, Ying-Xin Gu1
1Department of Implant Dentistry, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, People's Republic of China.
International Journal of Nanomedicine
|December 7, 2019
Summary
Tantalum (Ta) coatings on titanium (Ti) implants show excellent antimicrobial activity against peri-implantitis bacteria. Ta modification also enhances osseointegration, suggesting potential for improved dental implant success in infected situations.
Area of Science:
- Biomaterials Science
- Dental Implantology
- Microbiology
Background:
- Tantalum (Ta)-based coatings show promise for antibacterial activity.
- The precise mechanism and in vivo performance of Ta coatings on dental implants require further investigation.
- Understanding these factors is crucial for clinical translation of Ta-coated biomaterials.
Purpose of the Study:
- To investigate the antibacterial efficacy of Ta-modified titanium (Ti) implants against key peri-implantitis pathogens.
- To elucidate the molecular mechanisms underlying the antibacterial activity of Ta modification.
- To evaluate the in vivo biocompatibility and osseointegration potential of Ta-modified implants.
Main Methods:
- Antibacterial activity assessed against *Fusobacterium nucleatum* and *Porphyromonas gingivalis*.
- Potential antibacterial mechanisms explored, including micro-galvanic effects, ATP synthesis, and reactive oxygen species (ROS) generation.
- In vivo biocompatibility and osseointegration evaluated.
Main Results:
- Ta-modified surfaces demonstrated significant antimicrobial activity against tested bacteria.
- A micro-galvanic effect between Ta and Ti likely contributed to decreased bacterial ATP synthesis and increased ROS generation.
- Downregulation of bacterial virulence factors involved in attachment, invasion, and viability was observed.
- In vivo studies confirmed that Ta modification significantly enhanced osseointegration by promoting bone-forming protein expression.
Conclusions:
- Ta modification of Ti implants offers potent antibacterial properties against peri-implantitis-related microbes.
- The observed mechanisms involve disruption of bacterial energy metabolism and virulence.
- Ta modification promotes osseointegration, indicating potential for improved clinical outcomes, especially in infected sites.
