Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The pancreatic duct mucosal barrier.

H A Reber, C Roberts, L W Way

    American Journal of Surgery
    |January 1, 1979
    PubMed
    Summary

    The cat pancreatic duct has a strong barrier to bicarbonate ion diffusion. This barrier is damaged by infected bile, acidic aspirin, and ethanol, but not by sterile bile or less acidic aspirin.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Chronic sinusitis and bilateral deafness as a presentation of oesophageal stent failure: case report.

    The Journal of laryngology and otology·2008
    Same author

    Prevalence of type-specific HPV infection by age and grade of cervical cytology: data from the ARTISTIC trial.

    British journal of cancer·2008
    Same author

    Early experience with the TriMed fragment-specific fracture fixation system in intraarticular distal radius fractures.

    The Journal of hand surgery, European volume·2008
    Same author

    A systematic review of the effectiveness of strategies for reducing fracture risk in children with juvenile idiopathic arthritis with additional data on long-term risk of fracture and cost of disease management.

    Health technology assessment (Winchester, England)·2008
    Same author

    Cost-effectiveness of selective serotonin reuptake inhibitors and routine specialist care with and without cognitive behavioural therapy in adolescents with major depression.

    The British journal of psychiatry : the journal of mental science·2007
    Same author

    Phase I evaluation of CDP791, a PEGylated di-Fab' conjugate that binds vascular endothelial growth factor receptor 2.

    Clinical cancer research : an official journal of the American Association for Cancer Research·2007

    Area of Science:

    • Gastroenterology
    • Comparative Physiology
    • Pancreatic Biology

    Background:

    • The pancreatic duct's barrier function is crucial for preventing autodigestion.
    • Understanding this barrier's properties is key to understanding pancreatic diseases.

    Purpose of the Study:

    • To characterize the barrier properties of the feline pancreatic duct.
    • To identify agents that damage this bicarbonate diffusion barrier.

    Main Methods:

    • Perfusing the feline pancreatic duct with solutions mimicking pancreatic juice.
    • Assessing bicarbonate ion flux before and after exposure to various agents.
    • Evaluating damage by measuring net flux differences.

    Main Results:

    • The pancreatic duct barrier effectively limits bicarbonate ion (HCO3-) diffusion.
    • Infected bile, low pH aspirin, hydrochloric acid, ethanol, and secondary bile acids damaged the barrier.
    • Sterile bile, neutral pH aspirin, and primary bile acids did not damage the barrier.

    Conclusions:

    • The pancreatic duct barrier exhibits unique properties distinct from the gastric mucosal barrier.
    • The barrier's vulnerability to specific agents suggests a role in pancreatitis and pancreatic cancer pathogenesis.

    Related Experiment Videos