Related Experiment Video

Updated: Jan 2, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

16.4K

The emergence of neoadjuvant therapy in advanced melanoma

James Sun1, Dennis A Kirichenko2, Jonathan S Zager1

  • 1Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.

Melanoma Management
|December 7, 2019
PubMed

Insights

Immunotherapy and targeted therapy offer new advanced melanoma treatment options. Early neoadjuvant therapy trials show promise for managing this disease, paving the way for future melanoma advancements.

Area of Science:

  • Oncology
  • Dermatology
  • Cancer Therapeutics

Background:

  • Advanced melanoma previously had limited treatment options.
  • Immunotherapy and targeted therapy have emerged as effective treatments.
  • The neoadjuvant setting is a new frontier for these therapies.

Purpose of the Study:

  • To review the current literature on neoadjuvant therapy for advanced melanoma.
  • To summarize interim results from ongoing clinical trials.
  • To discuss future directions in neoadjuvant melanoma treatment.

Main Methods:

  • Literature review of existing studies.
  • Analysis of interim data from ongoing clinical investigations.
  • Synthesis of current and emerging neoadjuvant treatment strategies.

Main Results:

  • Neoadjuvant immunotherapy and targeted therapy are under active investigation.
  • Early clinical trial results are promising for advanced melanoma management.
  • These novel approaches offer new therapeutic avenues.

Conclusions:

  • Neoadjuvant therapy represents a significant advancement in treating advanced melanoma.
  • Ongoing research is crucial for optimizing these treatment strategies.
  • Future studies will further refine neoadjuvant options for melanoma patients.
Keywords:
advanced melanomabiochemotherapyimmunotherapyintralesional therapymelanomametastatic melanomaneoadjuvantoncolyticvirustargeted therapy

More Related Videos

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.8K
A Melanoma Patient-Derived Xenograft Model07:07

A Melanoma Patient-Derived Xenograft Model

Published on: May 20, 2019

13.0K

Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.6K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.6K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K