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Magnesium and liver disease.

Meixi Liu1, Huayu Yang1, Yilei Mao1

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Magnesium deficiency impacts liver disease progression by disrupting cellular functions. Supplementation may improve liver health in conditions like cirrhosis and hepatitis.

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Area of Science:

  • Biochemistry
  • Pathophysiology
  • Hepatology

Background:

  • Magnesium is an essential cation involved in numerous cellular processes.
  • Disturbances in magnesium balance are linked to various physiological and pathological conditions.
  • Magnesium deficiency is frequently observed in liver diseases, potentially stemming from reduced uptake or increased loss.

Purpose of the Study:

  • To comprehensively review magnesium concentration changes in liver diseases.
  • To elucidate the impact of magnesium levels on disease progression.
  • To explore the therapeutic potential of magnesium supplementation in liver conditions.

Main Methods:

  • Literature review of studies on magnesium and liver diseases.
  • Analysis of magnesium's role in cellular dysfunction.
  • Examination of magnesium's influence on specific liver conditions.

Main Results:

  • Low magnesium levels in serum and liver tissue correlate with the progression of liver diseases.
  • Magnesium deficiency contributes to mitochondrial dysfunction, inflammation, and oxidative stress.
  • Magnesium supplementation shows potential benefits for liver function in certain liver diseases.

Conclusions:

  • Magnesium homeostasis is critical for maintaining liver health.
  • Altered magnesium concentrations play a significant role in the pathogenesis of liver cirrhosis, alcoholic liver disease, liver cancer, and viral hepatitis.
  • Targeting magnesium levels could be a therapeutic strategy for managing liver diseases.