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Biomarkers in primary prevention : Meaningful diagnosis based on biomarker scores?

Christian Schulte1,2, Tanja Zeller3,4

  • 1Klinik für Kardiologie, Universitäres Herz- und Gefäßzentrum Hamburg, Martinistraße 52, 20246, Hamburg, Germany.

Herz
|December 7, 2019
PubMed

Insights

Cardiovascular risk assessment uses traditional factors. New biomarkers like cardiac troponins and genomic variations offer improved, personalized cardiovascular disease (CVD) risk stratification for primary prevention.

Area of Science:

  • Biomedical science
  • Cardiology
  • Preventive medicine

Background:

  • Cardiovascular (CV) risk assessment traditionally relies on established factors like smoking, diabetes, and hypertension.
  • Current risk scores guide clinical decisions for predicting CV pathologies and events.
  • Emerging biomarkers are being explored for enhanced risk stratification beyond acute diagnostics.

Purpose of the Study:

  • To review current knowledge on biomarkers for primary prevention of cardiovascular disease (CVD).
  • To present alternative biomarker-based strategies for CV risk assessment.
  • To explore the future potential of genomic variation and non-coding RNAs in personalized CVD risk stratification.

Main Methods:

  • Literature review of current research on CV biomarkers.
  • Analysis of traditional CV risk factors and their limitations.
  • Exploration of novel biomarkers including cardiac troponins, genomic variations, and non-coding RNAs.

Main Results:

  • Cardiac troponins show promise as markers for risk stratification in the general population.
  • Genomic variation and circulating non-coding RNAs represent potential future tools for CVD risk assessment.
  • Biomarker integration may lead to more personalized CV risk stratification.

Conclusions:

  • Biomarkers offer a promising avenue to enhance traditional CV risk assessment.
  • Novel biomarkers and genetic factors can refine personalized risk stratification for CVD prevention.
  • Further research into these markers is crucial for advancing primary prevention strategies.

Keywords:
Blood lipidsCardiovascular diseaseRisk assessmentRisk factorsTroponin

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