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European multicenter study of the TRUE Test
J M Lachapelle1, D P Bruynzeel, G Ducombs
1Unit and Laboratory of Occupational and Environmental Dermatology, Louvain University, Brussels, Belgium.
Contact Dermatitis
|August 1, 1988
Summary
The TRUE Test, a new patch test for contact dermatitis, showed 67% concordance with the Finn Chamber method. This standardized test offers a reliable alternative for diagnosing allergic contact dermatitis.
Area of Science:
- Dermatology
- Allergology
- Contact Dermatitis Research
Background:
- Contact dermatitis diagnosis relies on patch testing.
- Standardized and ready-to-apply patch tests can improve diagnostic efficiency.
- The TRUE Test is a novel patch test system.
Purpose of the Study:
- To evaluate the efficacy and concordance of the TRUE Test against the conventional Finn Chamber method.
- To assess the diagnostic performance of the TRUE Test in patients with suspected contact dermatitis.
Main Methods:
- A study involving 698 patients with suspected contact dermatitis.
- Comparison of the TRUE Test with the Finn Chamber technique using 12 common allergens.
- Symmetrical application of allergens on the upper back for both methods.
Main Results:
- All 12 allergens elicited positive reactions in the patient group.
- The TRUE Test demonstrated a 67% concordance with the Finn Chamber test.
- 13% of positive reactions were unique to the TRUE Test, while 20% were unique to the Finn Chamber method.
Conclusions:
- The TRUE Test is a viable and standardized method for diagnosing contact dermatitis.
- The TRUE Test shows good concordance with the established Finn Chamber technique.
- Both methods exhibited a low frequency (around 2%) of questionable or irritant reactions.