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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

33.8K

Safety and efficacy of catheter ablation in atrial fibrillation patients with left ventricular dysfunction

Songbing Long1, Yutao Xi2, Lianjun Gao3

  • 1Department of Cardiovascular, The Central Hospital of Shaoyang, Shaoyang, China.

Clinical Cardiology
|December 7, 2019
PubMed

Insights

Catheter ablation (CA) for atrial fibrillation (AF) in heart failure (HF) patients is safe and effective. This procedure reduces hospitalizations and mortality while improving heart function compared to medical therapy.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Heart Failure Management

Background:

  • Catheter ablation (CA) for atrial fibrillation (AF) in heart failure (HF) patients may increase complications, raising safety concerns.
  • Existing research suggests CA in HF patients might not increase complications compared to medical treatment.

Purpose of the Study:

  • To evaluate the safety and efficacy of CA for AF in patients with HF.
  • To compare CA outcomes in HF patients with those undergoing medical therapy and with patients having normal left ventricular ejection fraction (LVEF).

Main Methods:

  • A comparative study involving three groups: AF patients with congestive HF undergoing CA (AFHF-CA), AF patients with congestive HF on medical therapy (AFHF-Med), and AF patients with normal LVEF undergoing CA (AF-CA).
  • Follow-up duration was 30 ± 6 months.

Main Results:

  • Higher rates of maintaining sinus rhythm (SR) were observed in AFHF-CA (45.8%) and AF-CA (61.3%) groups compared to AFHF-Med (2.7%) (P<.01).
  • AFHF-CA demonstrated significantly lower HF hospitalizations and mortality rates compared to AFHF-Med (P<.01).
  • Significant improvements in heart function (LVEF, LV end-diastolic diameter, NYHA classification, left atrial diameter) were noted in AFHF-CA versus AFHF-Med (P<.01).

Conclusions:

  • Catheter ablation for AF in HF patients is associated with reduced hospitalizations and mortality.
  • CA improves cardiac function in HF patients compared to medical management.
  • The safety profile of CA for AF in HF patients is comparable to that in patients with normal heart function.
Abstract

Keywords:
antiarrhythmic drugsatrial fibrillationcatheter ablationheart failuremedication therapy

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