Related Experiment Video
Updated: Jan 2, 2026
05:31
Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
Published on: May 16, 2025
742
Matrix metalloproteinases and acute aortic dissection: Et Tu, Brute?
Hisato Takagi1,2, Yosuke Hari1,2, Kouki Nakashima1,2
1Department of Cardiovascular Surgery, Shizuoka Medical Center, Shizuoka, Japan.
Interactive Cardiovascular and Thoracic Surgery
|December 7, 2019
Summary
This meta-analysis found that matrix metalloproteinase-9 (MMP-9) levels are significantly higher in acute aortic dissection (AAD) patients. Elevated MMP-8 and MMP-12 may also be associated with AAD.
Area of Science:
- Cardiovascular Research
- Biomarkers
- Medical Diagnostics
Background:
- Matrix metalloproteinases (MMPs) play a role in extracellular matrix remodeling.
- Alterations in MMP levels have been implicated in various cardiovascular diseases.
- Acute aortic dissection (AAD) is a life-threatening condition with complex pathophysiology.
Purpose of the Study:
- To synthesize current evidence on the association between circulating matrix metalloproteinases (MMPs) and acute aortic dissection (AAD).
- To conduct the first meta-analysis comparing MMP levels in AAD patients versus control subjects.
Main Methods:
- A systematic literature search was conducted on PubMed and Web of Science up to July 2019.
- Case-control studies comparing circulating MMP levels in AAD patients and controls were included.
- Standardized mean differences (SMDs) were calculated and pooled using a random-effects model.
Main Results:
- Twelve studies with 458 AAD patients and 711 controls were analyzed.
- Significantly elevated levels of MMP-8, MMP-9, and MMP-12 were observed in AAD patients compared to controls.
- No significant differences in MMP-1, MMP-2, or MMP-3 levels were found between groups.
Conclusions:
- Circulating MMP-9 levels are significantly associated with acute aortic dissection (AAD).
- MMP-8 and MMP-12 may also be implicated in the pathophysiology of AAD.
- These findings highlight potential roles for specific MMPs as biomarkers in AAD.
