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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
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Migraine: a brain state amenable to therapy.
Michael Eller1, Peter J Goadsby2
1Monash Medical Centre, Melbourne, VIC.
The Medical Journal of Australia
|December 7, 2019
Summary
Migraine impacts over a billion people globally, causing significant disability and economic burden. Advances in understanding its pathophysiology are leading to new, targeted treatments and devices for better patient care.
Area of Science:
- Neuroscience
- Pharmacology
- Medical Research
Background:
- Migraine is a prevalent neurological disorder affecting over a billion people worldwide, representing a major cause of disability.
- It imposes substantial societal costs due to its significant morbidity and impact on quality of life.
Observation:
- Recent advancements in understanding migraine pathophysiology have been achieved through animal models and functional neuroimaging.
- The role of small peptides as neurotransmitters in the migraine network has been identified.
Findings:
- Elucidation of neurotransmitter roles has enabled the development of novel migraine therapeutics, validated by randomized controlled trials.
- Migraine-specific medications, offering improved safety and usability, are transitioning from research to clinical practice.
- Non-drug therapeutic devices are emerging as an alternative for patients.
Implications:
- Migraine is often underdiagnosed and undertreated, necessitating proactive management strategies.
- A proactive approach involving acute and preventive treatment plans, tailored to individual patients, is crucial.
- Management should include supportive care for comorbid medication overuse.
- The evolving landscape of migraine understanding and treatment promises improved patient outcomes.
