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Gottesfeld-Hohler Memorial Foundation Risk Assessment for Early-Onset Preeclampsia in the United States: Think Tank
Joshua A Copel1, Lawrence D Platt, John C Hobbins
1Departments of Obstetrics, Gynecology and Reproductive Sciences and Pediatrics, Yale School of Medicine, New Haven Connecticut; the Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, California; the University of Colorado, Denver, School of Medicine, Denver, Colorado; the Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago Illinois; Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts; the Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland Oregon; the Fetal Medicine Research Institute, Kings College Hospital, London, United Kingdom; the Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston Texas; the Department Obstetrics, Gynecology and Reproductive Sciences, University of Texas at Houston, Houston, Texas; the Department of Obstetrics and Gynecology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; the Department of Obstetrics and Gynecology, Wright State University, Dayton, Ohio; Women & Infants Hospital, Brown University, Providence, Rhode Island; and the Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Abstract:
Preeclampsia is responsible for significant maternal and neonatal morbidity and is associated with a substantial economic burden. Aspirin has been shown to be effective in decreasing the risk of preterm preeclampsia; however, there is no consensus on the target population for aspirin prophylaxis. In May 2018, the Gottesfeld-Hohler Memorial Foundation organized a working group meeting with the goal of identifying the optimal preeclampsia risk-assessment strategy and consequent intervention in the United States. The meeting brought together experts from the leading professional societies. We discussed available literature and trends in preeclampsia risk assessment, current professional guidelines for identifying women at risk for preeclampsia, prophylactic use of aspirin in the United States and Europe, cost-effectiveness data, and feasibility of implementation of different assessment tools and preventive strategies in the United States. We identified specific knowledge gaps and future research directions in preeclampsia risk assessment and prevention that need to be addressed before practice change.