Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Servo-Actuated 3D-Printed Disposable Microvalves for Automated, Scalable Organoid Culture in Standard Incubators.

bioRxiv : the preprint server for biology·2026
Same author

Conserved Cell Type Signatures Across the Brainstem and Spinal Cord in the Mouse Central Nervous System.

bioRxiv : the preprint server for biology·2026
Same author

Cloud-connected pluripotent stem cell platform enhances scientific identity in underrepresented students.

Stem cell reports·2026
Same author

CellBouncer, a unified toolkit for single-cell demultiplexing and ambient RNA analysis, reveals hominid mitochondrial incompatibilities.

Cell genomics·2026
Same author

A Cross-Species Enhancer-AAV Toolkit for Cell Type-Specific Targeting Across the Basal Ganglia.

bioRxiv : the preprint server for biology·2026
Same author

Microfluidic Control of Dorsal-Ventral Patterning Within a Single Forebrain Organoid.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Jan 2, 2026

Author Spotlight: Targeted Microinjection and Electroporation of Primate Cerebral Organoids for Genetic Modification
11:44

Author Spotlight: Targeted Microinjection and Electroporation of Primate Cerebral Organoids for Genetic Modification

Published on: March 24, 2023

4.8K

Reverse engineering human brain evolution using organoid models.

Mohammed A Mostajo-Radji1, Matthew T Schmitz1, Sebastian Torres Montoya2

  • 1Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94143, USA.

Brain Research
|December 7, 2019
PubMed
Summary

Investigating primate brain evolution is challenging due to limited experimental models. This study proposes using brain organoids and stem cells to explore genetic and developmental differences in primate neurogenesis.

Keywords:
Brain evolutionBrain organoidsInduced pluripotent stem cells

More Related Videos

Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function
07:13

Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function

Published on: November 29, 2024

1.8K
Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells
10:25

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells

Published on: January 23, 2018

22.1K

Related Experiment Videos

Last Updated: Jan 2, 2026

Author Spotlight: Targeted Microinjection and Electroporation of Primate Cerebral Organoids for Genetic Modification
11:44

Author Spotlight: Targeted Microinjection and Electroporation of Primate Cerebral Organoids for Genetic Modification

Published on: March 24, 2023

4.8K
Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function
07:13

Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function

Published on: November 29, 2024

1.8K
Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells
10:25

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells

Published on: January 23, 2018

22.1K

Area of Science:

  • Evolutionary biology
  • Neuroscience
  • Developmental biology

Background:

  • Primate brain evolution shows significant variation in size and organization.
  • Studying the genetic and developmental basis of these differences is hindered by a lack of experimental models.
  • Pluripotent stem cells and brain organoids offer a promising avenue for comparative studies.

Purpose of the Study:

  • To outline strategies for identifying evolved developmental differences between humans and non-human primates.
  • To explore the cellular and genetic mechanisms underlying these evolutionary changes.
  • To highlight the potential of organoid models in understanding primate brain evolution.

Main Methods:

  • Comparative analyses of primate species.
  • Isolation of pluripotent stem cell lines from diverse great apes.
  • Development and application of chimeric brain organoid cultures.
  • Utilizing genome engineering techniques.

Main Results:

  • The study proposes a framework for comparative organoid research.
  • It addresses challenges in stem cell isolation and organoid model reproducibility.
  • It focuses on identifying genetic and cellular mechanisms of neurodevelopmental evolution.

Conclusions:

  • Brain organoid models are crucial for studying primate brain evolution.
  • These models can elucidate the origins of cognitive differences.
  • Future research can decode changes in cellular organization, connectivity, and physiology.