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Updated: Jan 2, 2026

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
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Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Published on: July 5, 2017

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Advances on Natural Polyphenols as Anticancer Agents for Skin Cancer

Soraya Sajadimajd1, Roodabeh Bahramsoltani2, Amin Iranpanah3

  • 1Faculty of Science, Razi University, Kermanshah, Iran.

Pharmacological Research
|December 7, 2019
PubMed

Insights

Polyphenols, found in plants, show promise in preventing skin cancer metastasis by influencing key cellular pathways. This review highlights their potential in developing new anti-skin cancer therapies.

Area of Science:

  • Phytochemistry
  • Oncology
  • Molecular Biology

Background:

  • Polyphenols are vital phytochemicals in plants with known anticancer properties.
  • Skin cancer incidence and mortality necessitate research into effective chemopreventive agents.
  • Metastasis is a critical factor in skin cancer progression and patient outcomes.

Purpose of the Study:

  • To review the in vivo chemopreventive effects of purified polyphenols against skin cancer metastasis.
  • To identify specific polyphenols and their mechanisms of action in combating skin cancer.
  • To explore the potential of polyphenols in developing novel therapeutic strategies for skin cancer.

Main Methods:

  • Systematic literature review of studies published between 2000 and August 2019.
  • Inclusion of in vivo mechanistic studies using purified polyphenols.
  • Databases searched included Scopus, PubMed, and Cochrane Library.

Main Results:

  • 34 studies were included, focusing on polyphenols like anthocyanins, EGCG, quercetin, and resveratrol.
  • Polyphenols demonstrated chemopreventive effects against melanoma, a highly metastatic skin cancer.
  • Mechanisms involved modulation of angiogenesis, apoptosis, inflammation, proliferation, and key signaling pathways (e.g., EGFR/MAPK, mTOR/PI3K/Akt).

Conclusions:

  • Polyphenols effectively target multiple signaling pathways involved in skin carcinogenesis and metastasis.
  • Specific polyphenols exhibit significant potential as therapeutic agents against skin cancer.
  • Further research into polyphenols could lead to innovative anti-skin cancer strategies.
Keywords:
Polyphenolsdrug discoverymetastasissignaling pathwayskin cancer

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