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MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis

Liang Du1, Lu Wang2, Jinfeng Gan3

  • 1Department of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510632, China; Institute of Precision Cancer Medicine and Pathology, Department of Pathology, Jinan University Medical College, Guangzhou, Guangdong 510632, China; Cancer Research Center, Shantou University Medical College, Shantou, Guangdong 515041, China; Department of Biomedical Sciences of Cells & Systems, Section Molecular Cell Biology and Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen 9700 AD, the Netherlands.

Iscience
|December 7, 2019
PubMed
Summary

MTA3 suppresses cancer cell stemness and metastasis in esophageal cancer. The MTA3/SOX2OT/SOX2 pathway is crucial for cancer progression and may offer new therapeutic targets.

Keywords:
Biological SciencesCancerCell BiologyMolecular BiologyStem Cells Research

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