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Potential regulatory role of lncRNA-miRNA-mRNA axis in osteosarcoma

Jin-Yan Wang1, Yan Yang1, Yajun Ma1

  • 1Department of Oncology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing 210000, Jiangsu, PR China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|December 8, 2019
PubMed

Insights

This review explores the complex interactions between long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and messenger RNAs (mRNAs) in osteosarcoma (OS) development. Understanding these regulatory axes offers new avenues for osteosarcoma diagnosis and treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Osteosarcoma (OS) is a prevalent bone cancer in children and adolescents with unsatisfactory prognoses.
  • The molecular mechanisms driving OS pathogenesis remain incompletely understood.
  • Non-coding RNAs, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), are critical regulators of cellular processes.

Purpose of the Study:

  • To comprehensively review the regulatory relationships among lncRNAs, miRNAs, and mRNAs in OS.
  • To highlight the role of the lncRNA-miRNA-mRNA axis in OS development.
  • To identify novel diagnostic and therapeutic strategies for OS.

Main Methods:

  • Literature review of recent research on lncRNA-miRNA-mRNA interactions in OS.
  • Analysis of the regulatory mechanisms involving non-coding RNAs in OS pathogenesis.
  • Synthesis of findings on the lncRNA-miRNA-mRNA axis in OS.

Main Results:

  • lncRNAs, miRNAs, and mRNAs exhibit complex cross-regulatory interactions.
  • The lncRNA-miRNA-mRNA axis plays a significant role in OS development.
  • These interactions influence key pathological processes including proliferation, migration, and drug resistance.

Conclusions:

  • The lncRNA-miRNA-mRNA axis is a crucial determinant in osteosarcoma progression.
  • Further elucidation of these regulatory networks can lead to improved diagnostic markers.
  • Targeting the lncRNA-miRNA-mRNA axis presents promising therapeutic opportunities for osteosarcoma.
Keywords:
OsteosarcomalncRNAsmRNAmiRNAs

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