A short review on chemical properties, stability and nano-technological advances for curcumin delivery

Introduction: Curcumin is a polyphenol found in turmeric that is derived from the rhizomes of Curcuma longa. Curcumin has received a worldwide attention due to being a major constituent of the traditional Chinese and Indian holistic systems, and due to its well-documented pharmacological effects against various diseases.Areas covered: In order to provide a better understanding of curcumin's biological activities, its chemical, structural, spectral and photophysical properties should be studied. Also, it is crucial to study the aqueous, spectral, photophysical, photochemical, and thermal stability. Such studies indicated that curcumin suffers from bioavailability problems such as low serum levels, limited tissue distribution, and excessive metabolism which all limit its therapeutic efficacy. This review summarizes different properties of curcumin, its stability, bioavailability problems, and recent nanotechnological approaches with special highlight on nanocapsules for curcumin delivery.Expert opinion: Poor bioavailability of curcumin could be overcome through recently emerging and promising nanotechnological approaches.