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Early-Onset Noncommunicable Disease and Multimorbidity Among Adults With Pediatric-Onset Disabilities

Daniel G Whitney1, Rachael T Whitney2, Neil S Kamdar3

  • 1Department of Physical Medicine and Rehabilitation, Michigan Medicine, University of Michigan, Ann Arbor.

Mayo Clinic Proceedings
|December 8, 2019
PubMed

Insights

Young adults with pediatric-onset disabilities (PoDs) face significantly higher risks of developing major noncommunicable diseases and multimorbidity. Early detection and management are crucial for this vulnerable population.

Area of Science:

  • Public Health
  • Epidemiology
  • Disability Studies

Background:

  • Pediatric-onset disabilities (PoDs) can significantly impact long-term health trajectories.
  • Noncommunicable diseases (NCDs) are a leading cause of global mortality and morbidity.
  • Understanding NCD prevalence in young adults with PoDs is critical for targeted interventions.

Purpose of the Study:

  • To determine the prevalence of major noncommunicable diseases (NCDs) in young adults with pediatric-onset disabilities (PoDs).
  • To compare NCD prevalence and multimorbidity in young adults with and without PoDs.
  • To identify specific NCDs disproportionately affecting young adults with PoDs.

Main Methods:

  • Utilized a de-identified nationwide claims database (Optum Clinformatics Data Mart).
  • Included beneficiaries aged 18-40 years with diagnostic codes for childhood-originating PoDs.
  • Identified NCDs using ICD-9-CM codes and compared prevalence between groups, adjusting for sociodemographics.

Main Results:

  • Adults with PoDs exhibited significantly higher prevalences and odds of all studied NCDs (OR, 2.1-9.0; P<.05) and multimorbidity (OR, 3.8; 95% CI, 3.7-3.9).
  • All PoD categories, except for genital organ PoDs regarding ischemic and cerebrovascular diseases, showed increased NCD and multimorbidity prevalence.
  • This highlights a substantial burden of early-onset NCDs in young adults with PoDs.

Conclusions:

  • Young adults with PoDs experience an accelerated onset of major noncommunicable diseases.
  • These findings underscore the significant contribution of PoDs to the global disease and mortality burden.
  • Proactive healthcare strategies are essential for managing NCDs in this population.
Abstract

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