Related Experiment Video
Updated: Jan 2, 2026

Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium
Published on: March 4, 2016
Needle Embolization: Suspecting Needle Migration in Intravenous Drug Abusers
Mor Levy1, Barry Hahn1, Ryan Aycock2
1Department of Emergency Medicine, Staten Island University Hospital, Northwell Health, Staten Island, New York.
Central needle migration is a rare complication of intravenous drug abuse. Emergency physicians should suspect this condition in patients with a history of needle breakage and concerning symptoms like chest pain or fever.
Area of Science:
- Emergency Medicine
- Cardiology
- Radiology
Background:
- Intravenous drug abuse affects millions globally, with needle breakage a known risk.
- Central needle migration, though rare, is a serious complication of intravenous drug use.
- Cervical vein use in drug abusers increases risk for intravascular embolization.
Purpose of the Study:
- To highlight the rare but devastating complication of central needle migration in intravenous drug abusers.
- To emphasize the importance of considering needle embolization in emergency department patients with relevant history and symptoms.
- To review potential complications and diagnostic considerations for emergency physicians.
Main Methods:
- Case report of a 27-year-old male with a history of intravenous drug abuse presenting with neck pain after needle breakage.
- Computed tomography (CT) scan revealed a needle in the right ventricle with mediastinitis and jugular thrombus.
- Non-surgical management with broad-spectrum and oral antibiotics.
Main Results:
- A computed tomography scan confirmed a needle lodged in the right ventricle, causing mediastinitis and left internal jugular thrombus.
- The patient was successfully managed non-surgically and discharged on oral antibiotics.
- This case illustrates the potential for delayed diagnosis and serious complications.
Conclusions:
- Central needle migration is an underdiagnosed condition in intravenous drug users due to varied presentations.
- Emergency physicians must maintain a high index of suspicion for needle embolization in patients reporting needle breakage or presenting with unexplained symptoms.
- Prompt recognition and appropriate management are crucial to prevent severe sequelae such as cardiac perforation, thrombosis, and infection.
Related Concept Videos
Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Prevention of Further Absorption of Poison
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration
Routes of Drug Administration: Parenteral
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

