Related Experiment Video
Updated: Jan 2, 2026
09:51
Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
Published on: July 16, 2017
15.9K
GliomaDB: A Web Server for Integrating Glioma Omics Data and Interactive Analysis
Yadong Yang1, Yang Sui1, Bingbing Xie1
1CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Genomics, Proteomics & Bioinformatics
|December 8, 2019
Summary
GliomaDB is a new comprehensive database integrating multi-omics and clinical data for brain tumors like glioblastoma multiforme (GBM) and low-grade glioma (LGG). It aids researchers and clinicians in advancing precision medicine for glioma.
Area of Science:
- Neuro-oncology
- Bioinformatics
- Genomics
Background:
- Gliomas are common brain cancers with complex genetic underpinnings.
- Identifying diagnostic and therapeutic biomarkers is crucial for improving patient outcomes.
- Existing data resources are fragmented, hindering comprehensive analysis.
Purpose of the Study:
- To develop and present GliomaDB, a centralized, integrated database for glioma research.
- To provide a user-friendly platform for accessing and analyzing multi-omics and clinical data.
- To facilitate precision medicine by enabling personalized treatment recommendations.
Main Methods:
- Integrated data from TCGA, GEO, CGGA, MSK-IMPACT, FDA, and PharmGKB.
- Included genomic, transcriptomic, epigenomic, clinical, and gene-drug association data.
- Developed a web-based interface for data querying and analysis.
Main Results:
- GliomaDB contains data from 21,086 samples across 4303 patients.
- The database supports queries for somatic mutations, gene/miRNA expression, and DNA methylation.
- Enabled functionalities include survival analysis, network visualization, and drug recommendations.
Conclusions:
- GliomaDB consolidates diverse glioma datasets, bridging the gap between big data and actionable insights.
- The platform empowers researchers and clinicians to leverage integrated information for glioma studies.
- Facilitates the progression of precision medicine in the field of glioma.
