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Updated: Jan 2, 2026

Measuring Synaptic Vesicle Endocytosis in Cultured Hippocampal Neurons
Published on: September 4, 2017
Presynaptic endoplasmic reticulum and neurotransmission
Ilya Bezprozvanny1, Ege T Kavalali2
1Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9040, USA.
Abstract:
Synaptic transmission relies on rapid calcium (Ca2+) influx into presynaptic terminal via voltage-gated Ca2+ channels. However, smooth ER is present in presynaptic terminals and accumulating evidence indicate that ER Ca2+ signaling may play a modulatory role in synaptic transmission. Most recent publication by Lindhout and colleagues (EMBO J, 38 (2019) e101345) suggested that the fragmentation state of the ER affects synaptic vesicle release. Here we discuss these results as well as several key publications that addressed a connection between ER Ca2+ signaling and synaptic transmission.
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