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Updated: Jan 2, 2026

Evaluation of Nanoparticle Uptake in Tumors in Real Time Using Intravital Imaging
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Cancer Immunoimaging with Smart Nanoparticles.

Yu-Chuan Ou1, Xiaona Wen1, Rizia Bardhan2

  • 1Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA.

Trends in Biotechnology
|December 9, 2019
PubMed
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Smart nanoparticles enable dynamic immunoimaging in vivo, crucial for tailoring immunotherapies. This approach tracks immune cells and receptors, guiding treatment decisions for better patient outcomes.

Area of Science:

  • Immunology
  • Nanotechnology
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  • Dynamic immunoimaging in vivo is essential for personalized immunotherapies, including patient selection, efficacy monitoring, and strategy adjustment for non-responders.
  • Nanoparticles have become integral to immunotherapy, offering novel capabilities for in vivo applications.

Purpose of the Study:

  • To review recent advancements in immunoimaging utilizing smart nanoparticles for in vivo applications.
  • To highlight the role of nanoparticles in targeting, detecting, stimulating, and delivering therapeutic doses within the body.
  • To discuss how these nanoparticles facilitate image-guided interventions in immunotherapy.

Main Methods:

  • Integration of nanoparticles with advanced immunoimaging toolboxes.
  • Utilizing multiple imaging modalities for comprehensive tracking.
Keywords:
SPIOT cell trackingdendritic cell trackinggold nanoparticlesimage-guided immunotherapyimmunoimagingorganic nanoparticles

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  • Development of functional nanoparticles for tracking specific immune components.

    • Main Results:

    • Smart nanoparticles enable precise targeting, detection, stimulation, and therapeutic delivery in vivo.
    • Nanoparticle-enhanced immunoimaging allows for depth-resolved, whole-body tracking of immunomarkers with high accuracy.
    • Functional nanoparticles successfully track T cells, dendritic cells (DCs), tumor-associated macrophages (TAMs), and immune checkpoint receptors (ICRs).

    Conclusions:

    • Smart nanoparticles are transformative tools for dynamic immunoimaging in immunotherapy.
    • These nanoparticles enhance the ability to monitor immune responses and guide therapeutic interventions.
    • The integration of nanoparticles with imaging technologies improves patient-tailored treatment strategies.