Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jan 2, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

IgA pemphigus: A systematic review.

Khalaf Kridin¹, Payal M Patel², Virginia A Jones²

¹Department of Dermatology, Rambam Health Care Campus, Haifa, Israel.

Journal of the American Academy of Dermatology

|December 9, 2019

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

B7-H6/NKp30 Axis in Melanoma: Translational Rationale, Evidence Gaps, and Therapeutic Considerations.

Biomolecules·2026

Same author

Hiding in plain sight: Pathogenic insights from nonlesional skin in gliptin-associated bullous pemphigoid.

The Journal of investigative dermatology·2026

Same author

Pyoderma gangrenosum is associated with excess incident major atherothrombotic events.

Atherosclerosis·2026

Same author

PTPN6/SHP-1 in autoimmune disease: immune tolerance, regulatory mechanisms, and therapeutic targeting.

Frontiers in immunology·2026

Same author

A New Approach to Internal Nasal Lining Reconstruction: The Septal Artery Musculo-Mucosal Fornix (SAMM-F) Flap.

Annals of plastic surgery·2026

Same author

CD24 in Melanoma: Biomarker, Innate Immune Checkpoint and Emerging Therapeutic Target.

Experimental dermatology·2026

Same journal

Hypoactive Sexual Desire Disorder in Menopausal Women: Dermatologic Implications of Antiandrogen and Testosterone Therapy.

Journal of the American Academy of Dermatology·2026

Same journal

Incise parallel, section perpendicular to the dermatoglyphs for diagnosis of acral melanocytic lesions-A comment on Thakker et al.

Journal of the American Academy of Dermatology·2026

Same journal

Response to Xue et al, "Defining super-responders is not the same as predicting rituximab response in pemphigus".

Journal of the American Academy of Dermatology·2026

Same journal

Comment on Nie et al. (2026) 'Suicidality Reports in Acne Patients Treated with Isotretinoin and Concomitant Antidepressants: A Descriptive Analysis of FDA Adverse Event Reporting System Data'.

Journal of the American Academy of Dermatology·2026

Same journal

Defining super-responders is not the same as predicting rituximab response in pemphigus.

Journal of the American Academy of Dermatology·2026

Same journal

Eosinophilic fasciitis induced by checkpoint inhibitors: a retrospective multicenter case-series, comparison with eosinophilic fasciitis unrelated to checkpoint inhibition and literature review.

Journal of the American Academy of Dermatology·2026

See all related articles

IgA pemphigus often presents as vesiculopustular eruptions and circinate plaques. This systematic review synthesizes data on IgA pemphigus, highlighting common clinical features and treatments.

Area of Science:

Dermatology
Immunology
Autoimmune Blistering Diseases

Background:

IgA pemphigus (IgAP) is a rare autoimmune blistering disease.
Limited large-scale studies exist on IgAP's clinical, histologic, and immunopathologic characteristics.

Purpose of the Study:

To conduct a systematic review synthesizing available data on IgA pemphigus.
To consolidate information on the epidemiology, clinical presentation, histology, and immunology of IgAP.

Main Methods:

Systematic literature review of MEDLINE, Embase, and Web of Science databases.
Inclusion of case reports and case series of patients diagnosed with IgA pemphigus.

Main Results:

119 studies with 137 IgAP patients were analyzed (mean age 51.5 years).

Keywords:

IgA pemphigus immunoreactivity systematic review

More Related Videos

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases

Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases

Published on: July 3, 2025

Related Experiment Videos

Last Updated: Jan 2, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases

Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases

Published on: July 3, 2025

Common presentations included vesicles (80.8%), pustules (75.0%), circinate plaques (63.6%), and pruritus (65.6%).

Intercellular IgA deposition was found in 97.0% of patients; IgA gammopathy and ulcerative colitis were noted in 9.5% and 6.6%, respectively. Oral dapsone and corticosteroids were common treatments.

Conclusions:

IgA pemphigus diagnosis should be considered in patients with vesiculopustular eruptions and circinate plaques, particularly with truncal and extremity involvement.
Findings are primarily derived from case reports and small series, indicating a need for larger studies.