RIFM fragrance ingredient safety assessment, hydroxycitronellal dimethyl acetal, CAS Registry Number 141-92-4

Area of Science:

• Chemical safety assessment
• Toxicology
• Environmental risk evaluation

Background:

• Hydroxycitronellal dimethyl acetal is a fragrance ingredient requiring comprehensive safety evaluation.
• Previous data on the analog hydroxycitronellal diethyl acetal (CAS # 7779-94-4) informed the assessment.
• Regulatory compliance necessitates evaluation across multiple toxicity and environmental endpoints.

Purpose of the Study:

• To assess the safety profile of hydroxycitronellal dimethyl acetal for human health and the environment.
• To determine potential risks related to genotoxicity, systemic toxicity, local effects, and sensitization.
• To evaluate environmental persistence, bioaccumulation, and toxicity (PBT) characteristics.

Main Methods:

• Genotoxicity was predicted using read-across data from hydroxycitronellal diethyl acetal.
• Threshold of Toxicological Concern (TTC) approach was used for repeated dose, reproductive, and local respiratory toxicity.
• UV spectra analysis was employed for phototoxicity/photoallergenicity assessment.
• Environmental safety was evaluated against IFRA Environmental Standards, including PBT assessment and risk quotient calculation (PEC/PNEC).

Main Results:

• Hydroxycitronellal dimethyl acetal is not expected to be genotoxic.
• Exposure levels are below the TTC for systemic and local respiratory toxicity.
• No safety concerns for skin sensitization were identified at current use levels.
• The substance is not expected to be phototoxic or photoallergenic.
• Hydroxycitronellal dimethyl acetal is not considered PBT, and risk quotients are <1.

Conclusions:

• Hydroxycitronellal dimethyl acetal is considered safe for use regarding genotoxicity, systemic toxicity, local respiratory effects, and skin sensitization.
• The substance poses no phototoxic or photoallergenic risk.
• Environmental risk assessment indicates no adverse impact at current usage volumes, meeting IFRA standards.